In Vivo
Our team has been involved in the development of a range of animal models of respiratory disease which are offered to provide proof of concept and proof of mechanism of small molecules, biologics and vaccines.
Mouse models
Infection
- Human rhinovirus, RSV and influenza virus infection
- Streptococcus pneumoniae infection
Chronic airway disease
- House dust mite and ovalbumin asthma models
- Elastase/LPS COPD model
Viral exacerbations
- Rhinovirus-induced exacerbation of asthma
- Rhinovirus-induced exacerbation of COPD
In Vitro
We have extensive experience using in vitro models of cell biology and infection to deliver insights into mechanisms of respiratory disease and therapy efficacy and mechanism of action.
We offer a range of cell types and pathogens including:
Cell Types
Bronchial epithelial cells
- Cell lines e.g. A549, BEAS-2B, H292
- Primary bronchial epithelial cells from donors of various ages and disease status including healthy subjects, smokers, asthmatics and COPD
- Submerged cultures
- Air liquid interface (ALI) cultures
Monocytes/macrophages/dendritic cells
- Isolated primary cells (PBMC or BAL derived)
- THP-1 cells
- Monocyte-derived M0, M1 and M2 polarised macrophages
Lymphocytes
- Primary T cells (PBMC or tonsil derived)
Infectious agents
Viruses
- Human rhinovirus (RV)
- Respiratory Syncytial Virus (RSV)
- Influenza A
Bacteria
- Streptococcus pneumoniae
- Haemophilus influenzae
- Moraxella catarrhalis