In Vivo

Our team has been involved in the development of a range of animal models of respiratory disease which are offered to provide proof of concept and proof of mechanism of small molecules, biologics and vaccines.

Mouse models

Infection

• Human rhinovirus, RSV and influenza virus infection
• Streptococcus pneumoniae infection

Chronic airway disease

• House dust mite and ovalbumin asthma models
• Elastase/LPS COPD model

Viral exacerbations

• Rhinovirus-induced exacerbation of asthma
• Rhinovirus-induced exacerbation of COPD

In Vitro

We have extensive experience using in vitro models of cell biology and infection to deliver insights into mechanisms of respiratory disease and therapy efficacy and mechanism of action.

We offer a range of cell types and pathogens including:

Cell Types

Bronchial epithelial cells

• Cell lines e.g. A549, BEAS-2B, H292
• Primary bronchial epithelial cells from donors of various ages and disease status including healthy subjects, smokers, asthmatics and COPD
• Submerged cultures
• Air liquid interface (ALI) cultures

Monocytes/macrophages/dendritic cells

• Isolated primary cells (PBMC or BAL derived)
• THP-1 cells
• Monocyte-derived M0, M1 and M2 polarised macrophages

Lymphocytes

• Primary T cells (PBMC or tonsil derived)

Infectious agents

Viruses

• Human rhinovirus (RV)
• Respiratory Syncytial Virus (RSV)
• Influenza A

Bacteria

• Streptococcus pneumoniae
• Haemophilus influenzae
• Moraxella catarrhalis